cumulative percentage drug release vs time) for Koresmeyer-Peppas equation indicated a good linearity for the commercially available sustained release tablet and formulation F-3 with regression values of 0.9619 and 0.9959, respectively. Scanning electron microscope confirmed both diffusion and erosion mechanism for the optimized batch of matrix ... In vitro dissolution profiles of different formulations containing paracetamol sustained release matrix tablets, In vitro dissolution study was carried out in 0.1 N HCL (pH 1.2) for first 2hr and ... Preparation of sustained release matrix tablets Nevirapine sustained release matrix tablets were prepared by wet granulation technique[13,14]employing starch as a binder, okra gum as a release retarding polymer and lactose as a diluent to maintain the tablet weight. Six formulations F1-F6 using different percentages
For each formulation the hardness of 10 tablets was evaluated using Monsanto hardness tester (chambell electronics, India). The thickness of the 10 tablets was measured by electronic Vernier caliper (mitutoyo) japan. As the formulations one sustained release matrix tablet so there is no scope for disintegration test. Formulation and Evaluation Of Sustained Release Matrix Tablets of Lornoxicam Lornoxicam, a potent non-steroidal anti-inflammatory drug which has short half life, makes the development of sustained release (SR) forms extremely advantageous.
prepare sustained release matrix tablets of Aceclofenac and to study the effect of in vitro release characteristics, kinetics of the prepared formulations and stability studies 10 . Formulation, development and evaluation of Pregabalin sustained release matrix tablets Article (PDF Available) in Der Pharmacia Lettre 3(5):326-331 · September 2011 with 3,540 Reads according to the theoretical sustained release profile an sustained release formulation of Ondansetron hydrochloride should provide a release of 23.2% in 1 h, 45.8% in 4 h, 71.2% in 8 h and 104.4% in 12 h. formulation V tablets gave release profile near to theoretical sustained release needed for Ondansetron. The release from formulation
Formulation and Evaluation of a Sustained-Release Tablets of Metformin Hydrochloride Using Hydrophilic Synthetic and Hydrophobic Natural Polymers K. J. Wadher , * R. B. Kakde , 1 and M. J. Umekar Department of Pharmaceutical Technology, Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur-441 002, India Modified-release dosage and its variants are mechanisms used in tablets (pills) and capsules to dissolve a drug over time in order to be released slower and steadier into the bloodstream while having the advantage of being taken at less frequent intervals than immediate-release (IR) formulations of the same drug. forms extremely advantageous. The main objective of this work is formulation development of Meloxicam sustained release matrix tablets that provide complete drug release that starts in the stomach to rapidly alleviate the painful symptoms and continues in the intestine to maintain
Aim: The current paper was an attempt to design a sustained release dosage form using various grades of hydrophilic polymers, Hypromellose (hydroxyl-propyl methylcellulose [HPMC] K15M, HPMC K100M and HPMC K200M) and Polyacrylate polymers, Eudragit RL100 and Eudragit RS100 with or without incorporating ethyl cellulose on a matrix-controlled drug delivery system of Metformin hydrochloride. Formulation and Evaluation of Sustained Release Matrix Tablets of Furosemide Using Different Polymers ISSN (Print): 2521-8514 ISSN (Online): 2521-8484 RADS J. Pharm. Pharm. Sci. 145 methods i.e. peroral, topical, transmucosal and Sustained release profiles allow tailored dosing of the active ingredient over an extended period of time up to 24 hours. Common ways to achieve such release rates are the use of film coating, a sustained release matrix or sustained release drug-loaded granules. BASF offers powerful excipients that provide almost endless design space for sustained release formulations.
Sustained release matrix tablets prepared by wet granulation technique using microcrystalline ethyl cellulose polymer and Bees wax showed good sustaining drug release concluding that sustained release tablet could be successfully combined with accurate control and prolongation of the drug release patterns.[9,10] However, comparatively linear and desirable sustained release was obtained from EC-based matrix tablets prepared by slightly modifying the granulation method. Moreover, two different compression ... Matrix tablet is one of the most convenient approaches for the preparation of the sustained release dosage forms.Matrix tablets composed of drug and polymer as release retarding material offer the simplest approach in developing a sustained-release drug delivery system.
60 Research Article FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF TRAMADOL HYDROCHLORIDE RAGHAVENDRA RAO N. G 1*, GANDHI SAGAR 1, PATEL TARUN1 1PG Department of Pharmaceutics, Luqman College of Pharmacy, Old Jewargi Road, Gulbarga - 585 102. 2Department of Pharmaceutics, N.E.T. Pharmacy College, Raichur – 584 103. Tel: +91-9448570193 Aim: The present research work was to design and develop the sustained release matrix tablets of vildagliptin. It is having a short biological half-life (1.5 h) so it is considered as a suitable drug for the formulation of sustained release tablets to prolong its therapeutic action. Vildagliptin is an oral antihyperglycemic agent of In this book, method development for different tablet formulations to incorporate Cefuroxime Axetil in sustained release drug delivery system is described. Cefuroxime Axetil had saturation kinetics that could be overcome by slow release of drug from the formulation, by incorporating Cefuroxime Axetil in sustained release drug-delivery system ...
Sustained release matrix tablet is a delivery system by which the drug can be delivered at a controlled rate for long period of time. The present study aims at formulation, evaluation and optimization of captopril matrix tablets. A 3 full factorial ... Thus, sustained release matrix tablet can offer better patient compliance and could be quite helpful in treatment of chronic diseases. The present article concentrates on oral sustained release tablets with a special emphasis on matrix tablet. The release mechanism of matrix tablet followed zero order release kinetics. The finding of current investigation clearly indicates that the synthetic polymer was given a more sustained release profile than natural polymer on varied concentration. Conclusion: On comparing in vitro release of optimized formulation with marketed preparation, it ...
Extended release matrix tablets of Stavudine: Formulation and in vitro evaluation Article in Asian Journal of Pharmaceutics 4(3) · July 2010 with 48 Reads How we measure 'reads' once-daily sustained release formulation of aceclofenac is desirable2-5. For sustained release systems, the oral route of drug administration has, by far, received the most attention as it is natural, uncomplicated, convenient and safer route6. Matrix tablets composed of drug and release retarding material (e.g. polymer) offer the simplest ...
Formulation of Nifedipine sustained release matrix tablet was prepared by the polymers blend with to get desirable drug release profile. Evaluation parameters of formulated tablets were hardness, friability, thickness, drug content uniformity weight variation, and the in vitro drug release rate pattern. Preparation of sustained release matrix tablets Tablet formulation was prepared by wet granulation technique. All the powders were passed through BSS-80 mesh. Required quantities of Diclofenac sodium and other polymers (Cashew nut tree gum, HPMC and Carbopol) were mixed separately and thoroughly and a sufficient volume of Keywords: Levofloxacin, Xanthan gum, In vitro dissolution studies, Sustained release matrix tablets. INTRODUCTION Sustained drug delivery system was aimed to release the medication in a prolonged rate to maintain plasma drug levels. The drugs having shorter half life are suitable for the sustained drug delivery system. The main objective in ...
“Formulation and Evaluation of Sustained Release Matrix Tablet of BCS Class I Drug” is a bonafide and genuine research work carried out by me under the guidance of Dr. Bhanudas S. Kuchekar, Prinicipal, MAEER’s Sustained release matrix tablets containing 75 mg ambroxol hydrochloride were developed using different drug polymer ratios of hydroxypropyl methylcellulose. Tablets were prepared by direct compression. Formulation was optimized on the basis of acceptable tablet properties and in vitro drug release. The resulting formulation produced robust tablets with optimum hardness, consistent weight ...
FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF CAPTOPRIL Pankit Mehta*1, Gajanan.J.Deshmukh1, A.K.Seth 1, Patel Banty2 1Department of Pharmacy, Sumandeep Vidyapeeth University, Vadodara-391760, Gujarat, India 2Shri Sarvajanik Pharmacy College, GTU, Mehsana-384001, Gujarat, India Corresponding author Pankit Mehta methyl methacrylate (PMMA), Polyglycolic acid, HPMC etc. The matrix controls the release rate of drug. Release retardants like HPMC can aid in sustained release and thus they form core excipient of the formulation. The method involves the direct compression of blend of drug, retardant material and additives to formulate a tablet in ADVANTAGES OF MATRIX TABLET: 15-16 Easy to manufacture Versatile, effective and low cost Can be made to release high molecular weight compounds The sustained release formulations may maintain therapeutic concentrations over prolonged periods. The use of sustain release formulations avoids the high blood concentration.
Formulation & Evaluation of Sustained Release Matrix Tablet of Repaglinide Introduction Among the innumerable methods used for sustained release formulation matrix is the most popular approach. Hydrophilic or hydrophobic polymers are used as release retardants. Hydrophilic polymers are most widely used in matrix system because these The objective of the present study was to develop once-daily sustained-release matrix tablets of nicorandil, a novel potassium channel opener used in cardiovascular diseases. The tablets were prepared by the wet granulation method. Ethanolic solutions of ethylcellulose (EC), Eudragit RL-100, Eudragit RS-100, and polyvinylpyrrolidone were used as granulating agents along with hydrophilic matrix ...
Formulation and Evaluation of Sustained Release Matrix Tablets of Flurbiprofen by Using Natural and Synthetic Polymers Basavaraja*, Kirankumar Navade, B.Someswara Rao, Suresh V. Kulkarni Formulation and evaluation of sustained release matrix tablet of Tizanidine Hydrochloride by direct compression technique Dr. Rakesh P. Patel*, Mehul H. Patel*, Bhupendra G Prajapati*, Ashok H. Baria1 * Department of Pharmaceutics, S. K. Patel College of Pharmaceutical Education and
FORMULATION AND DEVELOPMENT OF SUSTAINED RELEASE MATRIX TABLETS OF METFORMIN HYDROCHLORIDE *Javed A.Mirza1, Dr. A.P.Pingle1, Nanasaheb Kale1, Mayur Gandhi1, Sandesh More1, Govind Dhongale1 1N.D.M.V.P Samajs College Of Pharmacy, Gangapur Road, Nashik ABSTRACT Objective of the present study is to formulate and evaluate the matrix FORMULATION AND EVALUTION OF SUSTAINED RELEASE ZIDOVUDINE MATRIX TABLETS HIMANSU 1BHUSAN 1SAMAL , S.A.SREENIVAS , 2SUDDHASATTYA DEY1AND HIMANSHU SHARMA 1GuruNanakInstituteof Pharmacy,Ibrahimpatnam, Hyderabad501506, 2Sandoz Pvt Ltd, Navi Mumbai1Email:email@example.com
Formulation and Evaluation of Sustained Release Matrix Tablets of Cephalexin: Effects of Hydrophilic and Hydrophobic Matrix on Drug Release N. Hingawe*1, S. Pandey2, D. Pardhi3 and A. Purohit 3 1 Department of Pharmaceutics, Sonekar College of Pharmacy, Devi Road, Mahadula, Koradi, Nagpur-441111, Maharashtra, India. A zero-order sustained-release delivery system for delivery of carbamazepine. A matrix tablet formulations of carbamazepine comprising hydrophilic polymer gel which inhibits transformation of carbamazepine into carbamazepine dihydrate by causing morphologic changes of carbamazepine crystals and results in amorphous form of carbamazepine present in the polymer matrix.
Abstract: Objective: The objective of the present study was to develop and evaluate once-daily sustained release matrix tablets of furosemide using hydroxypropylmethylcellulose K4M, xanthan gum ... sustained release tablets of enalapril are expected to avoid acute overdose, and to prevent morning hypertension . The other advantages of sustained release dosage forms are patient compliance, reduction of local and systemic side effects, minimization of peaks and valleys in drug blood levels .
sustained release formulation of glimepiride. Keywords: Glimepiride, Sustained release, Matrix tablets, Wet granulation. INTRODUCTION The oral route of administration is considered as the most widely accepted route because of its convenience of self administration, compactness and easy manufacturing (Sastry et al, 2000; Seager et al, 1998 ... 1.1 Sustained release delivery system 1 1.2 Factors influencing design and performance 7 1.3 Sustained release matrix system 14 1.4 Mechanism of hydrophilic matrix tablets 18 1.5 Drugs suitable for sustained release formulations 21 2. LITERATURE REVIEW 2.1 Literature Review on Glucosamine 26
Formulation and Evaluation of Glipizide Sustained Release Matrix Tablet Piyali Dey . Volume 2, Issue 10, October– 2017 International Journal of Innovative Science and Research Technology ISSN No: - 2456 – 2165 IJISRT17OC66 www.ijisrt.com 158 1. INTRODUCTION 1.1 DRUG DELIVERY SYSTEM: Oral drug delivery is the most widely utilized route of administration among all the routes that has been ... CERTIFICATE This is to certify that the dissertation entitled “FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF VENLAFAXINE HYDROCHLORIDE” the bonafide research work carried out by ARCHANA.M (Register No. 26116001) in the Department of Pharmaceutics, Adhiparasakthi College of Pharmacy, Melmaruvathur which is affiliated to The Tamil-